Alzheimer's and Parkinson's diseases are the two most common of a class of diseases known as neurodegenerative diseases, where brain cells sicken and die. Alzheimer's disease is a progressive neurologic disease that results in the irreversible loss of neurons, particularly in the cortex and hippocampus. Parkinson's disease is the second most common neurodegenerative disorder, after Alzheimer's disease. It is characterized clinically by parkinsonism (resting tremor, bradykinesia, rigidity, and postural instability) and pathologically by the loss of neurons in the substantia nigra and elsewhere in association with the presence of ubiquinated protein deposits in the cytoplasm of neurons (Lewy bodies) and thread-like proteinaceous inclusions within neurites (Lewy neurites)




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